Mark E. Humphrey, MD

Family Medicine


Mark E. Humphrey, MD, joined the faculty of the University of South Carolina School of Medicine in October 2013. Dr. Humphrey serves as the medical director for the Family Medicine Center. Prior to his appointment to the School of Medicine, Dr. Humphrey served as a medical and preventive medicine officer with the US Navy, where he completed a humanitarian tour to the South Pacific. He received his medical degree from the Boonshoft School of Medicine at Wright State University in Dayton, Ohio, and completed his family medicine residency at the University of Louisville community program in Glasgow, Kentucky. As a result of his interest in global health and health care policy, Dr. Humphrey completed a preventive medicine residency and a master's degree in public health at Johns Hopkins Bloomberg School of Public Health. A graduate of the University of Toledo, Dr. Humphrey received a bachelor of arts in chemistry and a minor in business administration. He is particularly interested in population-based quality improvement, community medicine, health care policy and global health.

Our Vision: To be known for clinical excellence and remembered for compassionate care.


Education and training

Specialty Family Medicine

Board CertifiedAmerican Board of Family Medicine; American Board of Preventive Medicine

EducationWright State Boonshoft School of Medicine

ResidencyJohns Hopkins Bloomberg School of Public Health, University of Louisville

Our affiliate system

Prisma Health is the largest not-for-profit health organization in South Carolina, serving more than 1.2 million patients annually. Our 30,000 team members are dedicated to supporting the health and well-being of you and your family. Palmetto Health-USC Medical Group will be rebranded at a later date and will continue to operate as a joint venture between the Midlands affiliate and the USC School of Medicine.

Our promise is to: Inspire health. Serve with compassion. Be the difference.

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Palmetto Health is becoming Prisma Health. Palmetto Health-USC Medical Group is part of Prisma Health.