Mark D. Locke, MD

Orthopedic Surgery
Clinical Assistant Professor of Orthopedic Surgery


Mark D. Locke, MD, received his medical degree from Case Western University Medical School in Cleveland. He completed his internship at Northwestern Memorial Hospital and his residency at Children's Memorial Hospital, both in Chicago, and completed a fellowship in pediatric orthopedics at Scottish Rite Hospital in Atlanta.

Dr. Locke is board certified by the American Board of Orthopaedic Surgery and is a fellow with the American Academy of Orthopaedic Surgeons, the American Academy of Pediatrics and the Scoliosis Research Society. He is a member of the Pediatric Orthopaedic Society of North America and the American Academy of Cerebral Palsy, has been named Best Orthopedic Surgeon in the Midlands by Best Doctors, and serves as a clinical assistant professor of orthopedic surgery with the University of South Carolina School of Medicine. His specialties and clinical interests include pediatric orthopedics, spinal deformity, scoliosis, and pediatric trauma.

“It’s great to be able to do things to help people with major problems and to do it safely. For pediatric orthopedics, you really have to understand the stresses and the other people involved; the dad, the mom, the grandparents, the coaches. So we have a whole family unit that you really have to identify, connect with and be there to support them.”


Education and training

Specialty Orthopedic Surgery

Board CertifiedAmerican Board of Orthopaedic Surgery

EducationCase Western University Medical School

ResidencyChildren's Memorial Hospital

FellowshipScottish Rite Children's Medical Center

Treatments and services
  • Pediatric orthopedics and trauma
  • Children’s fractures
  • Spinal deformity
  • Early onset scoliosis
  • Scoliosis casting/growing rods
  • Young adult hip disorders
  • Hand and foot deformity
  • Limb lengthening, external fixation
  • Special clinics for club feet and Spina Bifida
Professional associations
  • American Board of Orthopaedic Surgery
  • American Academy of Orthopaedic Surgeons
  • American Academy of Pediatrics
  • Scoliosis Research Society
  • Pediatric Orthopaedic Society of North America
  • American Academy of Cerebral Palsy

Our affiliate system

Prisma Health is the largest not-for-profit health organization in South Carolina, serving more than 1.2 million patients annually. Our 30,000 team members are dedicated to supporting the health and well-being of you and your family. Palmetto Health-USC Medical Group will be rebranded at a later date and will continue to operate as a joint venture between the Midlands affiliate and the USC School of Medicine.

Our promise is to: Inspire health. Serve with compassion. Be the difference.

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Palmetto Health is becoming Prisma Health. Palmetto Health-USC Medical Group is part of Prisma Health.